Both Cannabis transdermal and topical have staked a big claim in the medical marijuana market. The two patches have been known to exhibit differences in their operation, effects, and benefits. They both have an inspiring awe since their inception in the medical sector. Topical medication is normally intended to affect the site of application while the transdermal is intended to reach areas away from the site of application. The use of topical medication results in minimal significant drug concentrations in the blood while in the case of transdermal, it acts as a better method for patients intending to have the medicine metabolized in the blood.
Transdermal is frequently used for anti-nausea drugs and hormone replacement therapy. Cannabis topical is absorbed directly through the skin to solve mild localized pains and inflammations.
They include balms, salves, lotions, and oils that have been infused with active cannabinoids. Therefore, are applied to the skin directly. Some have penetrated massage oils and cosmetics zone, leaving an additional benefit to the user.
Transdermal medications usually in the form of a patch are a little more modern, and a little more complex. The first transdermal drug, scopolamine, to treat motion sickness, was approved by the FDA in , and great strides in transdermal drug delivery have been made since then. Transdermal drug delivery systems, or TDDS, bring medication through the skin beyond the site of application to the bloodstream. Once in the blood, the ingredients circulate and take effect at a targeted location — the brain, the central nervous system, the heart, etc.
Medication is delivered steadily, and can be stopped by simply removing the patch. The science of transdermal drug delivery has advanced materially since the first patch in The latest delivery systems use microneedles, thermal ablation, and other sophisticated methods to pass medication through the skin.
For example, microneedles and thermal ablation are currently being used for delivery of insulin, parathyroid hormone, and influenza vaccine among others. The impact on medicine and on the health of patients is meaningful. This is expected to continue as scientific advancements allow for more therapies to be delivered transdermally.
At Altasciences, we have completed hundreds of studies in every major category of topical and transdermal products. Our high-precision, computerized adhesion assessment process, using ImageJ software and other proprietary tools, offers enhanced adhesion determination capabilities. Our database of over , participants ensures that we get your study up and running, fast, and our excellent retention rates maximize validity of data. From nicotine patches to narcotic implants to antibiotic creams, we have the knowledge and experience to help you assess your transdermal and topical medications.
Continuing advances in skin penetration enhancement are allowing new and old drugs to be administered transdermally, providing prolonged therapeutic effects and improved patient safety. Understanding the formulation and penetration differences between topical and transdermal medications is crucial to selecting the appropriate product for a specific use.
Medications that are intended to exert clinical effects at distant or deeper tissue sites require a purpose-designed transdermal vehicle. These vehicles gels, patches, films, etc. However, the clinician should be aware not all patches or topical gels are transdermal.
Most creams, gels, ointments and patches are merely topical formulations with limited, if any, drug penetration to the tissues and circulation below the skin.
Drug delivery to the skin. In: Physiological Pharmaceutics, Biological Barriers to drug absorption. Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. Epidermal lipids, membranes, and keratinization. Drug permeation through human skin: Theory and in vitro experimental measurement. Lipid protein partition theory of skin penetration enhancement. Targeted drug delivery to the skin and deeper tissues; The role of physiology, solute structure, and disease.
Permeability of the skin. Physiol Rev [8] Mitragotri S. Breaking the skin barrier. Novel mechanisms and devices to enable successful transdermal drug delivery.
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